Maarso 31, 2026, Xarunta Qiimaynta Daawada ee Maamulka Badeecadaha Caafimaadka Qaranka ee Shiinaha ayaa soo bandhigtay war xiiso leh: GFH375, oo ay soo saartay GenFleet Therapeutics, ayaa si rasmi ah loogu daray musharax "Daawaynta Horumarka" ee daaweynta bukaanada qaba kansarka ganaca ee faafa ee qaba isbeddelka KRAS G12D kuwaas oo helay ugu yaraan hal daaweyn oo nidaamsan oo hore. Tani waxay calaamad u tahay tallaabo muhiim ah oo hore loogu qaaday daaweynta saxda ah ee kansarka ganaca.
Haddii adiga ama qof aad jeceshahay uu la halgamayo kansarka ganaca ee KRAS G12D-mutant, ha lumin rajada. Waaxda Caalamiga ah ee Isbitaalka Oncology ee Gobolka Koonfureed ee Beijing (400-880-3716) ayaa si dhow ula socota horumarkan casriga ah waxayna bixisaa adeegyo la-talin xirfadeed iyo isku-dubarid daaweyn ah oo loogu talagalay bukaanada caalamiga ah.
**Ku saabsan GFH375/VS-7375**
GFH375 waa daawo afka laga qaato oo awood leh, awood badan, oo aad u xulasho badan oo molecule yar oo KRAS G12D (ON/OFF) ah oo loogu talagalay in lagu beegsado is-weydaarsiga GTP/GDP, taasoo carqaladeynaysa dhaqdhaqaaqa marinnada hoose iyo si wax ku ool ah u joojinaysa faafitaanka unugyada burooyinka. Daraasadaha kahor-kiliinikada waxay muujiyeen xannibaad ku-tiirsan qiyaasta moodooyinka wata isbeddellada KRAS G12D; GFH375 waxay sidoo kale muujisay khatar hoose oo ka baxsan bartilmaameedka ee xulashada kinase iyo baaritaannada bartilmaameedka badbaadada.
GenFleet waxay la gashay iskaashi daahfur iyo horumarin ah Verastem Oncology (Nasdaq: VSTM) si ay u horumariso saddex barnaamij oo cusub oo kansar ah oo lagu bartilmaameedsanayo kansarka ku saleysan marinnada RAS/MAPK. Iskaashigani wuxuu siinayaa Verastem ikhtiyaar gaar ah si uu u helo ruqsad mid kasta oo ka mid ah saddexda isku-dhafan ka dib markii si guul leh loo dhammaystiray marxalado hore loo sii qorsheeyay tijaabadii Wajiga I. Bishii Diseembar 2023, Verastem waxay dooratay GFH375/VS-7375, oo ah daawo afka laga qaato oo KRAS G12D (ON/OFF), oo ah barnaamijkeeda hormuudka ah ee iskaashiga, ruqsadda GFH375 ee la sameeyay Janaayo 2025 ayaa ahayd tii ugu horreysay ee iskaashigan. Ruqsadaha waxay siinayaan horumarinta Verastem iyo xuquuqda ganacsi ee ka baxsan Shiinaha, halka GenFleet ay haysato xuquuqda gudaha Shiinaha.
**Xogta tijaabada caafimaad ee wejiga I/II ee rajo leh oo lagu soo bandhigay Shirweynihii ESMO ee 2025:**
- 91.5% bukaannada ayaa la kulmay hoos u dhac ku yimid nabarrada bartilmaameedka ah
- Heerka jawaab celinta ujeeddada (ORR) wuxuu gaaray 40.7%
- Heerka xakamaynta cudurrada (DCR) wuxuu ahaa mid aad u sarreeya ilaa 96.7%
- Badbaadinta dhexdhexaadka ah ee aan horumarka lahayn (mPFS) waxay ahayd 5.52 bilood
- Heerka badbaadada ee aan horumarka lahayn ee 4 bilood wuxuu ahaa 78.2%
Xogtan, oo laga soo qaatay 59 bukaan oo qaba KRAS G12D-mutant pancreatic ductal adenocarcinoma (PDAC) oo horumarsan oo helay daaweyn nidaamsan oo hore, ayaa si xooggan u muujinaysa firfircoonida xooggan ee ka hortagga burooyinka ee GFH375 ee kansarka ganaca ee aan firfircoonayn.
**Maxaad u dooratay Waaxda Caalamiga ah ee Isbitaalka Oncology ee Gobolka Koonfureed ee Beijing?
Iyada oo hormuud ka ah adeegyada caafimaadka caalamiga ah, Waaxda Caalamiga ah ee Isbitaalka Oncology ee Gobolka Koonfureed ee Beijing waxay ka go'an tahay inay siiso bukaanada caalamiga ah:
- Adeegyada la-talinta caafimaad ee xirfadleyda ah iyo ballanta iyo adeegyada ballanta ee luqado badan ku hadla
- Helitaanka khubarada hormuudka ka ah cudurka kansarka ee Shiinaha iyo caalamkaba
- Kanaal cagaaran oo hal joogsi ah oo loogu talagalay daaweynta caafimaad ee xuduudaha ka gudba
Waxaan fahamsanahay in bukaanada qaba kansarka horumaray, maalin kasta oo dheeraad ah oo la sugayo ay keento khatar weyn. Sidaa darteed, waxaan samaynay kanaallo caalami ah oo badan oo ku habboon si loo hubiyo inaad hesho taageero xirfadeed oo waqtigeeda ku habboon.
**Nala soo xiriir maanta oo bilow safarkaaga rajada**
��� Khadka Tooska ah: 400-880-3716
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- 100085_010@163.com
- myimmnet@163.com
Iyadoo aan loo eegin waddanka ama gobolka aad ku sugan tahay, ama inta ikhtiyaar ee daawaynta ee aad hore u tijaabisay, Waaxda Caalamiga ah ee Isbitaalka Oncology ee Gobolka Koonfureed ee Beijing waxay diyaar u tahay inay kula garab istaagto dagaalkaaga ka dhanka ah kansarka. Horumarka GFH375 wuxuu noqon karaa iftiinka aad sugeysay.
Call 400-880-3716, add us on WeChat at 17801183037, or email us at 100085_010@163.com or myimmnet@163.com.
Wadajir, aan ku dadaalno fursado badan oo nolosha ah.
> Fiiro gaar ah: GFH375 weli si rasmi ah looma ansixin suuqgeynta dhul-weynaha Shiinaha. Magacaabista Daaweynta Horumarka ah waxaa la filayaa inay dardar geliso helitaanka caafimaad. Waaxda Caalamiga ah ee Isbitaalka Oncology ee Gobolka Koonfureed ee Beijing ayaa si dhow ula socon doonta horumarka helitaanka daawada waxayna bixin doontaa macluumaad ku saabsan daaweynta casriga ah iyo adeegyada isku-dubaridka ee bukaanada u qalma. Fadlan raac tilmaamaha dhakhtarkaaga ee ku saabsan qorshayaasha daaweynta gaarka ah.
Waqtiga boostada: Abriil-10-2026